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Is physician-diagnosed allergic rhinitis a risk factor for the development of asthma

Is physician-diagnosed allergic rhinitis a risk factor for the development of asthma

Is physician-diagnosed allergic rhinitis a risk factor for the development of asthma?

Allergy. 2010 Feb 4;

Authors: van den Nieuwenhof L, Schermer T, Bosch Y, Bousquet J, Heijdra Y, Bor H, van den Bosch W, van Weel C

To cite this article: van den Nieuwenhof L, Schermer T, Bosch Y, Bousquet J, Heijdra Y, Bor H, van den Bosch W, van Weel C. Is physician-diagnosed

allergic rhinitis a risk factor for the development of asthma? Allergy 2010; DOI: 10.1111/j.1398-9995.2009.02316.x.

Abstract

Background: There is strong evidence that there is a relationship between allergic rhinitis (AR) and asthma, but it is unclear whether there is a causal relation between AR and asthma. The aim of this study was to assess

prospectively whether AR is a risk factor for the diagnosis of asthma in a large primary care population.

Methods: We performed a historic cohort study of life-time morbidity that had been recorded prospectively since 1967 in four general practices. Two groups of subjects were selected: (i) patients with diagnosis of AR, (ii) a control group matched using propensity scores. We assessed the risk of

physician-diagnosed asthma in patients with physician-diagnosed AR compared to subjects without a diagnosis of AR (controls).

Results: The study population consisted of 6491 subjects (n = 2081 patients with AR). Average study follow-up was 8.4 years. In patients with AR, the frequency of newly diagnosed asthma was 7.6% (n = 158) compared to 1.6% (n = 70) in controls (P < 0.001). After adjusting the effect of AR on asthma

diagnosis for registration time, age, gender, eczema and socioeconomic status,

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